human growth hormone - 2025 PACE NSC

Question

Alanine scanning mutagenesis was introduced to inhibit this protein's binding to its namesake receptor. Deficiency in this protein is a childhood symptom of Prader–Willi syndrome, so injections (0[2])of a version of this protein (0[1])are a common treatment for it and for both SHOX deficiency (20[1])and Turner syndrome. This protein is involved (0[1])in a negative feedback loop in which it stimulates IGF-1 (20[1])production in the (20[1])liver. (20[1]0[1])The most abundant (20[1])cell type (20[1])in the anterior (0[2])(*) pituitary gland secretes this protein in short pulses (10[1]0[1])that are regulated by (10[1])somatostatin and (10[1])somatocrinin. (10[1]0[2])Until growth (0[1])plate fusion, (10[1])greater abundance (10[2])of this protein increases height. (10[3])For (10[1])10 points, (10[4]0[1])name this hormone (10[1])whose deficiency (10[2])causes short stature. (10[3])■END■ (10[12]0[2])

ANSWER: human growth hormone [or hGH or somatotropin or somatropin or recombinant human growth hormone or rhGH; accept answers without "hormone" or "H" after "hormone" is read]

= Average correct buzz position

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Buzzes

Player	Team	Opponent	Buzz Position	Value
Colette Kendrick	Winston Churchill A	Glenbrook South	26	0
Aaryan Sumesh	Thomas Jefferson A	Uni of Illinois Laboratory	26	0
Alex Bach	Yukon A	Irvington	32	0
Samy El-Zahabi	Chattahoochee B	Detroit Catholic Central B	43	20
Joshua Koch	Grosse Pointe South	Park Tudor	50	0
Andrew Zhao	Richard Montgomery	Westwood	60	20
Kaiden Lee	Northview	Strake Jesuit A	63	20
Sreekar Vajjha	Classen SAS	Great Valley	64	0
Aadi Pudasaini	Lexington	Montgomery Blair A	64	20
Matthew Yang	Centennial B	Carl Sandburg	67	20
Anna Liao	Carmel B	Quince Orchard	69	20
Cormac Kennedy	Saint Joseph	Kane County AT	72	0
Kartik Bhat	Solon	Lincoln-Way East A	72	0
Ophelia Cherry-Pulay	Uni School of Nashville A	Montgomery Blair B	80	0
Ethan Kral	Northmont	Walter Payton A	80	10
Maxwell Swann	Centennial A	Downingtown STEM	84	10
Anirudh "Ani" Srinivasan	Adlai E. Stevenson A	Strake Jesuit B	86	10
Pranav Srambikkal	Lambert A	Detroit Catholic Central A	87	0
Tate Osborne	Alabama Cyber Tech	Innovation Academy A	87	0
Sophia Guo	Thomas Jefferson B	Milton	87	10
Harini Ramakrishnan	Saratoga	Seven Lakes	89	0
Kiran Patel	Barrington	Georgetown Day	91	10
Amber Dong	Adlai E. Stevenson B	Wayzata	93	10
Camden Williams	Audrain County AT	Hunter A	93	10
Aaron Zhang	Walter Payton B	Lee's Summit	98	10
Nomuun Undrakh	Eastchester	Lindbergh	98	10
Amy Tan	North Quincy	Coronado	98	10
Camille Pimentel	Hunter B	Fairfield County AT	99	10
Edward Kim	Johns Creek	Hinsdale Central A	101	10
Ian Droessler Wilson	Innovation Academy B	Uni School of Nashville B	101	10
Jack O’Brien	Edina	Parkway West	101	10
Justin Yuan	Thomas Jefferson E	Thomas Jefferson C	101	10
Henry Nolan	Herron	White Pigeon	101	0
Karthik Jayaram	Walker	Carmel A	104	10
Omkar Marathe	Fremd	Belmont	106	10
Adhrit Yadav	Lambert B	Northside College Prep	106	10
Snehan Saroch	Russell	Okemos	109	10
Sophia Chen	Uni of Illinois Laboratory	Thomas Jefferson A	109	10
George Aljarbo	Detroit Catholic Central C	Thomas Jefferson D	109	10
Tarun Devi	Chattahoochee A	West Point	110	10
Neel Rege	Great Valley	Classen SAS	110	10
Chris Goolsby	Detroit Catholic Central A	Lambert A	110	10
James Wray	Glenbrook South	Winston Churchill A	110	10
Shaun Iyer	Innovation Academy A	Alabama Cyber Tech	110	10
Arjun Murugappan	Irvington	Yukon A	110	10
Jeev Hora	Kane County AT	Saint Joseph	110	10
Yongle Xin	Montgomery Blair B	Uni School of Nashville A	110	0
Oreoluwa Sarah Owolabi	Homewood-Flossmoor	Page	110	10
Evan Ting	Park Tudor	Grosse Pointe South	110	10
Samin Asif	Seven Lakes	Saratoga	110	10
Felix Sacks	Lincoln-Way East A	Solon	110	10
Reily Gillenwater	Virginia	Lincoln-Way East B	110	0
Claire Lohse	White Pigeon	Herron	110	10

Summary

Tournament	Edition	Exact Match?	TUH	Conv. %	Power %	Neg %	Average Buzz
2025 PACE NSC	06/07/2025	Y	41	95%	15%	0%	95.90