Question

Early research on this process is surveyed in Yuri Lazebnik's paper "Can a biologist fix a radio?" During this process, certain enzymes perform auto·proteo·lytic cleavage of their pro·domains, allowing them to form "initiator" tetra·mers that activate "effector" tetra·mers. A pathway central to this process in C. elegans involves (20[4]0[1])CED-9, (20[7])CED-4, (20[3])CED-3, (20[2]0[2])and the BH3-only (20[1])protein EGL-1. The DISC is formed by (*) Fas receptors in the (10[1])"extrinsic" (10[1])pathway for this process, (0[1])whose "intrinsic" (10[1])pathway involves BCL2 family proteins regulating the release of (0[1])cytochrome (10[1])c in the mitochondria. (10[5])Caspases (10[1])drive markers of this process like blebbing and DNA (10[1])fragmentation. (10[2])For 10 points, (10[1])name this process of programmed (10[2])cell death. ■END■ (10[3])

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